Principal Investigators affiliated with the CTO program:



Principal Investigator


Research Area



Borel-Rinkes, I.H.M.


The responses in the human body to surgery that stimulate tumor growth or the formation of metastases.



Hillegersberg van, Richard


Malignant diseases of the upper gastrointestinal tract.



Grevenstein van, Helma


Laparoscopic gastro-intestinal and oncological surgery (including robotsurgery).



Kranenburg, Onno


Metastatic colon cancer.



Molenaar, Quintus


Pancreas and liver surgery.



Ruurda, Jelle


Clinical aspects of operations on esophagus and stomach.



Valk, G.D.


M.E.N.-syndrome, pituitary gland disorders, Addison’s disease and endocrine autoimmune diseases.



Vriens, Menno


Multiple endocrine neoplasia (MEN), thyroid cancer and pancreatic cancer.



Witkamp, A.J.


Hyperthermic intraperitoneal chemotherapy in peritoneal surface malignancy.

Head and Neck Surgical Oncology   Van Es, R.J.J.  

Individualized treatment and personalized Head Neck cancer care based on Image-guided and Molecular-guided treatment.




Bovenschen, Niels


How do the granzymes normally kill tumor cells and how can tumor cells escape from the cytotoxic immune response.


Brosens, Lodewijk

  The genetics of cystic preneoplastic pancreatic tumors (IPMN) and the transition to pancreatic carcinoma.



Derksen, Patrick


How does loss of cell-cell adhesion lead to tumour progression, with an emphasis on breast cancer.



Diest van, P.


Unraveling the origin of breast cancer optimalization of the diagnostics and treatment of breast cancer.



Lacle, Miangela M.


Identification of behavior in early invasive colorectal cancer.



Leng de, W.W.J.


Polyposis and tumorigenesis in Peutz-Jeghers Syndrome.



Linn, Sabine


1) Understanding the molecular mechanisms underlying differential anti-cancer drug sensitivity in breast and ovarian cancer patients in order to develop tests that may guide treatment decisions in the clinic and ultimately improve survival.

2) Impact of prognostic molecular classifiers on adjuvant systemic treatment advice in breast cancer.



Moelans, C.B.


Unraveling the genesis of breast cancer and to optimize the diagnostics and treatment of this disease.



Offerhaus, Johan


Unraveling the molecular and genetic mutations that cause cancer in the digestive tract.



Willems, Stefan


Molecular Pathology of head and neck carcinoma.




Erpecum van, Karel


Loco-regional treatment of liver malignancies.



Fidder, H.





Linde ter, Jose


Chemoprevention, early detection, and correct diagnosis of colorectal adenomas and cancer.



Moons, L.M.G.


 Detection and endoscopic treatment of early colorectal cancer.



Oldenburg, Bas


Understanding Crohn’s disease and colitis ulcerosa to offer patients better treatment and a better quality of life.



Vleggaar, Frank


Clinical trials studying new therapeutic endoscopic procedures (i.e. endo-ultrasound pain blockade and transmural drainages, endoscopic (sub)mucosal resections of early gastro-intestinal cancers in the digestive tract and palliative stent placements).



Fauser, B.C.J.M.


Ovarian function.



Zweemer, Ronald


Ovarian cancer, (micro)-metastases in cervical cancer and minimal invasive surgery within gynaecological oncology.




Gilhuijs, Kenneth


Translational imaging in breast oncology: decision support systems for patient tailored therapy selection.



Raaymakers, B.


Thermal modelling for hyperthermia.




Lam, Marnix


Individualized treatment in nuclear oncology and personalized cancer care based on image-guided treatment.


Veterinary Medicine


Bruin de, Alain


Unraveling the mystery of polyploidy in the liver and to discover the mechanism of tumor suppression by atypical E2Fs.


Medical Oncology


Witteveen, Els


Phase 1 and 2 studies in cancer patients with solid tumors to explore the safety and tolerance, and sometimes preliminary efficacy of a new medicine.

An overview of recent studies



Koopman, Miriam


Colorectal cancer: Phase 3 CAIRO studies of the Dutch Colorectal Cancer Group (DCCG) and observational cohort studies (PICNIC).






Vos de, Filip


Primary brain tumors.



Wall van der, Elsken


Elucidating cellular and angiogenetic pathways that result in breast cancer (development).


Julius Center


Elias, Sjoerd


Epidemiological studies of breast cancer.



Gils van, Carla


The additional value of MRI for women with extremely dense breasts in the population-based breast cancer screening program in the Netherlands.



Onland, Charlotte


Molecular end genetic epidemiology of breast- and ovarian cancer.



Peeters, Petra


Risk assessment and prevention of cancer with a focus on nutrition, lifestyle, biomarkers and genes.







Broekman, Marike


Brain tumors with the focus on extracellular vesicles.



Robe, Pierre


Resistance mechanisms that are activated in tumor cells as a reaction to therapy.


Clinical Chemistry & Haematology


Schiffelers, Raymond


Synthetic and natural nanoparticles (~100 nm) for therapy and diagnosis.


Translational Immunology


Nierkens, Stefan


Immunomonitoring and immunotherapy.








Molecular Cancer Research


Lens, Susanne


Unraveling the molecular principles that ensure faithful chromosome segregation during cell division, to understand how and why the fidelity of this segregation process is disturbed in cancer cells.