Research

Dept

Principal Investigator

Research Area

Surgery

Borel-Rinkes, I.H.M.

The responses in the human body to surgery that stimulate tumor growth or the formation of metastases.

Hillegersberg van, Richard

Malignant diseases of the upper gastrointestinal tract.

Grevenstein van, Helma

Laparoscopic gastro-intestinal and oncological surgery (including robotsurgery).

Kranenburg, Onno

Metastatic colon cancer.

Molenaar, Quintus

Pancreas and liver surgery.

Ruurda, Jelle

Clinical aspects of operations on esophagus and stomach.

Valk, G.D.

M.E.N.-syndrome, pituitary gland disorders, Addison’s disease and endocrine autoimmune diseases.

Vriens, Menno

Multiple endocrine neoplasia (MEN), thyroid cancer and pancreatic cancer.

Witkamp, A.J.

Hyperthermic intraperitoneal chemotherapy in peritoneal surface malignancy.

Individualized treatment and personalized Head Neck cancer care based on Image-guided and Molecular-guided treatment.

Pathology

Bovenschen, Niels

How do the granzymes normally kill tumor cells and how can tumor cells escape from the cytotoxic immune response.

Brosens, Lodewijk

Derksen, Patrick

How does loss of cell-cell adhesion lead to tumour progression, with an emphasis on breast cancer.

Diest van, P.

Unraveling the origin of breast cancer optimalization of the diagnostics and treatment of breast cancer.

Lacle, Miangela M.

Identification of behavior in early invasive colorectal cancer.

Leng de, W.W.J.

Polyposis and tumorigenesis in Peutz-Jeghers Syndrome.

Linn, Sabine

1) Understanding the molecular mechanisms underlying differential anti-cancer drug sensitivity in breast and ovarian cancer patients in order to develop tests that may guide treatment decisions in the clinic and ultimately improve survival.

2) Impact of prognostic molecular classifiers on adjuvant systemic treatment advice in breast cancer.

Moelans, C.B.

Unraveling the genesis of breast cancer and to optimize the diagnostics and treatment of this disease.

Offerhaus, Johan

Unraveling the molecular and genetic mutations that cause cancer in the digestive tract.

Willems, Stefan

Molecular Pathology of head and neck carcinoma.

 MDL

Erpecum van, Karel

Loco-regional treatment of liver malignancies.

Fidder, H.

Linde ter, Jose

Chemoprevention, early detection, and correct diagnosis of colorectal adenomas and cancer.

Moons, L.M.G.

 Detection and endoscopic treatment of early colorectal cancer.

Oldenburg, Bas

Understanding Crohn’s disease and colitis ulcerosa to offer patients better treatment and a better quality of life.

Vleggaar, Frank

Gynaecology

Fauser, B.C.J.M.

Ovarian function.

Zweemer, Ronald

Ovarian cancer, (micro)-metastases in cervical cancer and minimal invasive surgery within gynaecological oncology.

Radio-therapy

Gilhuijs, Kenneth

Translational imaging in breast oncology: decision support systems for patient tailored therapy selection.

Raaymakers, B.

Thermal modelling for hyperthermia.

Radiology

Lam, Marnix

Individualized treatment in nuclear oncology and personalized cancer care based on image-guided treatment.

Veterinary Medicine

Bruin de, Alain

Unraveling the mystery of polyploidy in the liver and to discover the mechanism of tumor suppression by atypical E2Fs.

Medical Oncology

Witteveen, Els

Phase 1 and 2 studies in cancer patients with solid tumors to explore the safety and tolerance, and sometimes preliminary efficacy of a new medicine.

An overview of recent studies

Koopman, Miriam

Colorectal cancer: Phase 3 CAIRO studies of the Dutch Colorectal Cancer Group (DCCG) and observational cohort studies (PICNIC).

Websites:

link

link

Vos de, Filip

Primary brain tumors.

Wall van der, Elsken

Elucidating cellular and angiogenetic pathways that result in breast cancer (development).

Julius Center

Elias, Sjoerd

Epidemiological studies of breast cancer.

Gils van, Carla

The additional value of MRI for women with extremely dense breasts in the population-based breast cancer screening program in the Netherlands.

Onland, Charlotte

Molecular end genetic epidemiology of breast- and ovarian cancer.

Peeters, Petra

Risk assessment and prevention of cancer with a focus on nutrition, lifestyle, biomarkers and genes.

Websites:

link

link

Neuro-Oncology

Broekman, Marike

Brain tumors with the focus on extracellular vesicles.

Robe, Pierre

Resistance mechanisms that are activated in tumor cells as a reaction to therapy.

Clinical Chemistry & Haematology

Schiffelers, Raymond

Synthetic and natural nanoparticles (~100 nm) for therapy and diagnosis.

Translational Immunology

Nierkens, Stefan

Immunomonitoring and immunotherapy.

Websites:

link

link

Movies:

link

link

Molecular Cancer Research

Lens, Susanne

Unraveling the molecular principles that ensure faithful chromosome segregation during cell division, to understand how and why the fidelity of this segregation process is disturbed in cancer cells.