Research
Principal Investigators affiliated with the CTO program:
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Principal Investigator |
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Research Area |
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Surgery |
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The responses in the human body to surgery that stimulate tumor growth or the formation of metastases. |
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Malignant diseases of the upper gastrointestinal tract. |
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Laparoscopic gastro-intestinal and oncological surgery (including robotsurgery). |
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Metastatic colon cancer. |
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Pancreas and liver surgery. |
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Clinical aspects of operations on esophagus and stomach. |
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M.E.N.-syndrome, pituitary gland disorders, Addison’s disease and endocrine autoimmune diseases. |
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Multiple endocrine neoplasia (MEN), thyroid cancer and pancreatic cancer. |
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Hyperthermic intraperitoneal chemotherapy in peritoneal surface malignancy. |
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| Head and Neck Surgical Oncology | Van Es, R.J.J. |
Individualized treatment and personalized Head Neck cancer care based on Image-guided and Molecular-guided treatment. |
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Pathology |
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How do the granzymes normally kill tumor cells and how can tumor cells escape from the cytotoxic immune response. |
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| The genetics of cystic preneoplastic pancreatic tumors (IPMN) and the transition to pancreatic carcinoma. | ||||
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How does loss of cell-cell adhesion lead to tumour progression, with an emphasis on breast cancer. |
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Unraveling the origin of breast cancer optimalization of the diagnostics and treatment of breast cancer. |
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Identification of behavior in early invasive colorectal cancer. |
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Leng de, W.W.J. |
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Polyposis and tumorigenesis in Peutz-Jeghers Syndrome. |
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1) Understanding the molecular mechanisms underlying differential anti-cancer drug sensitivity in breast and ovarian cancer patients in order to develop tests that may guide treatment decisions in the clinic and ultimately improve survival.
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Unraveling the genesis of breast cancer and to optimize the diagnostics and treatment of this disease. |
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Unraveling the molecular and genetic mutations that cause cancer in the digestive tract. |
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Molecular Pathology of head and neck carcinoma. |
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MDL |
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Loco-regional treatment of liver malignancies. |
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Linde ter, Jose |
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Chemoprevention, early detection, and correct diagnosis of colorectal adenomas and cancer. |
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Detection and endoscopic treatment of early colorectal cancer. |
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Understanding Crohn’s disease and colitis ulcerosa to offer patients better treatment and a better quality of life. |
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Clinical trials studying new therapeutic endoscopic procedures (i.e. endo-ultrasound pain blockade and transmural drainages, endoscopic (sub)mucosal resections of early gastro-intestinal cancers in the digestive tract and palliative stent placements). | |
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Gynaecology |
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Ovarian function. |
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Ovarian cancer, (micro)-metastases in cervical cancer and minimal invasive surgery within gynaecological oncology. |
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Radio-therapy |
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Translational imaging in breast oncology: decision support systems for patient tailored therapy selection. |
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Thermal modelling for hyperthermia. |
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Radiology |
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Individualized treatment in nuclear oncology and personalized cancer care based on image-guided treatment. |
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Veterinary Medicine |
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Unraveling the mystery of polyploidy in the liver and to discover the mechanism of tumor suppression by atypical E2Fs. |
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Medical Oncology |
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Phase 1 and 2 studies in cancer patients with solid tumors to explore the safety and tolerance, and sometimes preliminary efficacy of a new medicine. |
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Colorectal cancer: Phase 3 CAIRO studies of the Dutch Colorectal Cancer Group (DCCG) and observational cohort studies (PICNIC). Websites: |
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Primary brain tumors. |
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Elucidating cellular and angiogenetic pathways that result in breast cancer (development). |
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Julius Center |
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Epidemiological studies of breast cancer. |
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The additional value of MRI for women with extremely dense breasts in the population-based breast cancer screening program in the Netherlands. |
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Molecular end genetic epidemiology of breast- and ovarian cancer. |
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Risk assessment and prevention of cancer with a focus on nutrition, lifestyle, biomarkers and genes. Websites: |
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Neuro-Oncology |
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Brain tumors with the focus on extracellular vesicles. |
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Resistance mechanisms that are activated in tumor cells as a reaction to therapy. |
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Clinical Chemistry & Haematology |
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Synthetic and natural nanoparticles (~100 nm) for therapy and diagnosis. |
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Translational Immunology |
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Immunomonitoring and immunotherapy. Websites: Movies: |
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Molecular Cancer Research |
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Unraveling the molecular principles that ensure faithful chromosome segregation during cell division, to understand how and why the fidelity of this segregation process is disturbed in cancer cells. |